Deimination restores inner retinal visual function in murine demyelinating disease.

Deimination restores inner retinal visual function in a demyelinating disease

Role of Deimination for Protein Synthesis in Neuronal Cells

of a dissertation at the University of Miami. Dissertation supervised by Associate Professor Sanjoy K. Bhattacharya No. of pages in text. (94) Deimination refers to conversion of protein-bound arginine into citrulline. In contrast to global hyper-deimination in the brain and eyes, we have found local hypo-deimination in the retinal ganglion cell layer of patients and in a transgenic mouse model...

Nyctalopin expression in retinal bipolar cells restores visual function in a mouse model of complete X-linked congenital stationary night blindness.

Mutations in the NYX gene that encodes the protein nyctalopin cause congenital stationary night blindness type 1. In no b-wave (nob) mice, a mutation in Nyx results in a functional phenotype that includes the absence of the electroretinogram b-wave and abnormal spontaneous and light-evoked activity in retinal ganglion cells (RGCs). In contrast, there is no morphological abnormality in the retin...

THERAPEUTIC EFFECTS OF LASER PHOTOCOAGULATION AND VITRECTOMY IN EALES\'DISEASE

Eales' disease is an idiopathic obliterative retinal vasculopathy that is treated with laser photocoagulation, and/or vitrectomy. In order to determine visual outcomes and regression of retinal neovascularization following scattered peripheral retinal photocoagulation, and/or vitrectomy in cases with Eales' disease, we did a retrospective study of the records of these patients treated in La...

Ectopic Expression of a Microbial-Type Rhodopsin Restores Visual Responses in Mice with Photoreceptor Degeneration

The death of photoreceptor cells caused by retinal degenerative diseases often results in a complete loss of retinal responses to light. We explore the feasibility of converting inner retinal neurons to photosensitive cells as a possible strategy for imparting light sensitivity to retinas lacking rods and cones. Using delivery by an adeno-associated viral vector, here, we show that long-term ex...